Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation.

ABSTRACT: In addition to maintaining bile acid, cholesterol and glucose homeostasis, farnesoid X receptor (FXR) also regulates fatty acid β-oxidation (FAO). To explore the different roles of hepatic and intestinal FXR in liver FAO, FAO-associated metabolites, including acylcarnitines and fatty acids, and FXR target gene mRNAs were profiled using an integrated metabolomic and transcriptomic analysis in control (Fxr^fl/fl), liver-specific Fxr-null (Fxr^ΔHep) and intestine-specific Fxr-null (Fxr^ΔIE) mice, treated either with the FXR agonist obeticholic acid (OCA) or vehicle (VEH). Activation of FXR by OCA treatment significantly increased fatty acyl-CoA hydrolysis (Acot1) and decreased FAO-associated mRNAs in Fxr^fl/fl mice, resulting in reduced levels of total

SUBMITTER: Lu D 

PROVIDER: S-EPMC8864892 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature