Dataset Information

Flexibly Controlling the Polycrystallinity and Improving the Foaming Behavior of Polylactic Acid via Three Strategies.

ABSTRACT: Controlling foamability plays the central role in preparing PLA foams with high performances. To achieve this, chain extension was often used to improve the rheological property of PLA resins; however, despite the availability of this approach, it often deteriorates the biodegradability of PLA and greatly increases the processing cost and complexity. Hence, we reported a special crystallization induction method to design PLA foams with a tunable cellular structure and a high expansion ratio. A novel crystallization-promoting agent combination (D-sorbitol, CO₂, and phenylphosphonic acid zinc salt) was used to induce PLA to enhance the chain interaction force and chain mobility and to provide crystallization templets. A series of PLAs with tunable stereocomplex (Sc)/α crystallinity and rapid non-isothermal crystallization ability were obtained. The effect of various crystallization properties on the foaming behavior of PLA was studied. The results demonstrated that proper crystallization conditions (a small spherulite size, a crystallinity of 6%, and rapid crystallization ability) could virtually contribute to the optimized cellular structure with the highest cell density of 4.36 × 10⁶ cell/cm³. When the Sc crystallinity was above 10%, PLA had a superior foamability, which thereby resulted in a high foaming expansion ratio of 16.2. A variety of cellular morphologies of PLA foams could be obtained by changing the foaming temperature and the crystallization property. The proposed crystallization-induced approach provided a useful method for controlling the cellular structure and the performances of the PLA foams.

SUBMITTER: Liu W

PROVIDER: S-EPMC8867551 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Flexibly Controlling the Polycrystallinity and Improving the Foaming Behavior of Polylactic Acid via Three Strategies.

Liu Wei W Wu Xian X Chen Xiaocheng X Liu Shan S Zhang Chun C

ACS omega 20220209 7

Controlling foamability plays the central role in preparing PLA foams with high performances. To achieve this, chain extension was often used to improve the rheological property of PLA resins; however, despite the availability of this approach, it often deteriorates the biodegradability of PLA and greatly increases the processing cost and complexity. Hence, we reported a special crystallization induction method to design PLA foams with a tunable cellular structure and a high expansion ratio. A n ...[more]

PMID: 35224387

Similar Datasets

Project description:BackgroundCritical bone defects remain challenges for clinicians, which cannot heal spontaneously and require medical intervention. Following the development of three-dimensional (3D) printing technology is widely used in bone tissue engineering for its outstanding customizability. The 3D printed scaffolds were usually accompanied with growth factors, such as bone morphometric protein 2 (BMP-2), whose effects have been widely investigated on bone regeneration. We previously fabricated and investigated the effect of a polylactic acid (PLA) cage/Biogel scaffold as a carrier of BMP-2. In this study, we furtherly investigated the effect of another shape of PLA cage/Biogel scaffold as a carrier of BMP-2 in a rat calvaria defect model and an ectopic ossification (EO) model.MethodThe PLA scaffold was printed with a basic commercial 3D printer, and the PLA scaffold was combined with gelatin and alginate-based Biogel and BMP-2 to induce bone regeneration. The experimental groups were divided into PLA scaffold, PLA scaffold with Biogel, PLA scaffold filled with BMP-2, and PLA scaffold with Biogel and BMP-2 and were tested both in vitro and in vivo. One-way ANOVA with Bonferroni post-hoc analysis was used to determine whether statistically significant difference exists between groups.ResultThe in vitro results showed the cage/Biogel scaffold released BMP-2 with an initial burst release and followed by a sustained slow-release pattern. The released BMP-2 maintained its osteoinductivity for at least 14 days. The in vivo results showed the cage/Biogel/BMP-2 group had the highest bone regeneration in the rat calvarial defect model and EO model. Especially, the bone regenerated more regularly in the EO model at the implanted sites, which indicated the cage/Biogel had an outstanding ability to control the shape of regenerated bone.ConclusionIn conclusion, the 3D printed PLA cage/Biogel scaffold system was proved to be a proper carrier for BMP-2 that induced significant bone regeneration and induced bone formation following the designed shape.

Dataset Information

Flexibly Controlling the Polycrystallinity and Improving the Foaming Behavior of Polylactic Acid via Three Strategies.

Publications

Flexibly Controlling the Polycrystallinity and Improving the Foaming Behavior of Polylactic Acid via Three Strategies.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets