The sustained PGE₂ release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model.

ABSTRACT:

Background

The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration. Increasing evidence revealed that prostaglandin E₂ (PGE₂), a lipid signaling molecule, has significant therapeutic potential for tissue repair and regeneration. Though PGE₂ has been well reported in tissue regeneration, the application of PGE₂ is hampered by its short half-life in vivo and the lack of a viable system for sustained release of PGE₂.

Results

In this study, we designed and synthesized a new PGE₂ release matrix by chemically bonding PGE₂ to collagen. Our results revealed that the PGE₂ matrix effe

SUBMITTER: Huang H 

PROVIDER: S-EPMC8867652 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature