Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal.

ABSTRACT:

Background

Gut microbial alteration is implicated in inflammatory bowel disease but is noted in other diseases. Systematic comparison to define similarities and specificities is hampered since most studies focus on a single disease.

Results

We develop a pipeline to compare between disease cohorts starting from the raw V4 16S amplicon sequence variants. Including 12,838 subjects, from 59 disease cohorts, we demonstrate a predominant shared signature across diseases, indicating a common bacterial response to different diseases. We show that classifiers trained on one disease cohort predict relatively well other diseases due to this shared signal, and hence, caution should be taken when using such classifiers in real-world scenarios, where diseases are intermixed. Based on this

SUBMITTER: Abbas-Egbariya H 

PROVIDER: S-EPMC8867743 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature