Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms.

ABSTRACT: T-cell development in the thymus undergoes the process of differentiation, selective proliferation, and survival from CD4^-CD8^- double negative (DN) stage to CD4⁺CD8⁺ double positive (DP) stage prior to the formation of CD4⁺ helper and CD8⁺ cytolytic T cells ready for circulation. Each developmental stage is tightly regulated by sequentially operating molecular networks, of which only limited numbers of transcription regulators have been deciphered. Here, we identified Zfp335 transcription factor as a new player in the regulatory network controlling thymocyte development in mice. We demonstrate that Zfp335 intrinsically controls DN to DP transition, as T-cell-specific deficiency in Zfp335 leads to a substantial

SUBMITTER: Wang X 

PROVIDER: S-EPMC8871394 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature