Dataset Information

An Assessment of GPX1 (rs1050450), DIO2 (rs225014) and SEPP1 (rs7579) Gene Polymorphisms in Women with Endometrial Cancer.

ABSTRACT:

Background

Numerous studies indicate a relationship between the presence of GPX1 (rs1050450), DIO2 (rs225014) and SEPP1 (rs7579) gene polymorphisms and the development of chronic or neoplastic diseases. However, there are no reports on the influence of these polymorphisms on the development of endometrial cancer.

Methods

543 women participated in the study. The study group consisted of 269 patients with diagnosed endometrial cancer. The control group consisted of 274 healthy women. Blood samples were drawn from all the participants. The PCR-RFLP method was used to determine polymorphisms in the DIO2 (rs225014) and GPX1 (rs1050450) genes. The analysis of polymorphisms in the SEPP1 (rs7579) gene was performed by means of TaqMan probes.

Results

There was a 1.99-fold higher risk of developing endometrial cancer in CC homozygotes, DIO2 (rs225014) polymorphism (95% Cl 1.14-3.53, p = 0.017), compared to TT homozygotes. There was no correlation between the occurrence of GPX1 (rs1050450) and SEPP1 (rs7579) polymorphisms and endometrial cancer.

Conclusion

Carriers of the DIO2 (rs225014) polymorphism may be predisposed to the development of endometrial cancer. Further research confirming this relationship is recommended.

SUBMITTER: Janowska M

PROVIDER: S-EPMC8871918 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

An Assessment of <i>GPX1</i> (rs1050450), <i>DIO2</i> (rs225014) and <i>SEPP1</i> (rs7579) Gene Polymorphisms in Women with Endometrial Cancer.

Janowska Magdalena M Potocka Natalia N Paszek Sylwia S Skrzypa Marzena M Żulewicz Kamila K Kluz Marta M Januszek Sławomir S Baszuk Piotr P Gronwald Jacek J Lubiński Jan J Zawlik Izabela I Kluz Tomasz T

Genes 20220121 2

<h4>Background</h4>Numerous studies indicate a relationship between the presence of <i>GPX1</i> (rs1050450), <i>DIO2</i> (rs225014) and <i>SEPP1</i> (rs7579) gene polymorphisms and the development of chronic or neoplastic diseases. However, there are no reports on the influence of these polymorphisms on the development of endometrial cancer.<h4>Methods</h4>543 women participated in the study. The study group consisted of 269 patients with diagnosed endometrial cancer. The control group consisted ...[more]

PMID: 35205233

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