Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in Hydra Regeneration.

ABSTRACT: The emergence and stabilization of a body axis is a major step in animal morphogenesis, determining the symmetry of the body plan as well as its polarity. To advance our understanding of the emergence of body axis polarity, we study regenerating Hydra. Axis polarity is strongly memorized in Hydra regeneration even in small tissue segments. What type of processes confer this memory? To gain insight into the emerging polarity, we utilize frustrating initial conditions by studying regenerating tissue strips which fold into hollow spheroids by adhering their distal ends of opposite original polarities. Despite the convoluted folding process and the tissue rearrangements during regeneration, these tissue strips develop in a reproducible manner, preserving the original polarity and yielding an o

SUBMITTER: Shani-Zerbib L 

PROVIDER: S-EPMC8872179 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature