Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction.

ABSTRACT: Severe sepsis induces a sustained immune dysfunction associated with poor clinical behavior. In particular, lymphopenia along with increased lymphocyte apoptosis and decreased lymphocyte proliferation, enhanced circulating regulatory T cells (Treg), and the emergence of myeloid-derived suppressor cells (MDSCs) have all been associated with persistent organ dysfunction, secondary infections, and late mortality. The mechanisms involved in MDSC-mediated T cell dysfunction during sepsis share some features with those described in malignancies such as arginine deprivation. We hypothesized that increasing arginine availability would restore T cell function and decrease sepsis-induced immunosuppression. Using a mouse model of sepsis based on cecal ligation and puncture and secondary pneumonia tri

SUBMITTER: Reizine F 

PROVIDER: S-EPMC8872724 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature