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Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection.

ABSTRACT: The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here, we outline the multistep mechanisms of lung epithelial and endothelial injury induced by SARS-CoV-2: direct viral infection, chemokine/cytokine-mediated damage, and immune cell-mediated lung injury. Finally, we discuss the recent progress in terms of antiviral therapeutics as well as the development of anti-inflammatory or immunomodulatory therapeutic approaches. This review also provides a systematic overview of the models for studying SARS-CoV-2 infection and discusses how an understanding of mechanisms of lung injury will help identify potential targets for future drug development to mitigate lung injury.

SUBMITTER: Upadhya S

PROVIDER: S-EPMC8873036 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection.

Upadhya Samsara S Rehman Jalees J Malik Asrar B AB Chen Shuibing S

Physiology (Bethesda, Md.) 20211026 2

The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here, we outline the multistep mechanisms of lung epithelial and endothelial injury induced by SARS-CoV-2: direct viral infection, chemokine/cytokine-mediated damage, and immune cell-mediated lung injury. Finally, we discuss the recent progress in terms of antiviral therapeutics as well as the development of anti-inflammatory or immunomodulatory therapeutic approaches. This review also provides a systematic overvi ...[more]

PMID: 34698589

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