Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics.

ABSTRACT: The mechanical behavior of tissues at the macroscale is tightly coupled to cellular activity at the microscale. Dermal wound healing is a prominent example of a complex system in which multiscale mechanics regulate restoration of tissue form and function. In cutaneous wound healing, a fibrin matrix is populated by fibroblasts migrating in from a surrounding tissue made mostly out of collagen. Fibroblasts both respond to mechanical cues, such as fiber alignment and stiffness, as well as exert active stresses needed for wound closure. Here, we develop a multiscale model with a two-way coupling between a microscale cell adhesion model and a macroscale tissue mechanics model. Starting from the well-known model of adhesion kinetics proposed by Bell, we extend the formulation to account for nonl

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8874030 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature