Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC8880557 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Wang Feng F Li Shan S Cheng Kai-Wen KW Rosencrans William M WM Chou Tsui-Fen TF
Pharmaceuticals (Basel, Switzerland) 20220207 2
The diverse modes of action of small molecule inhibitors provide versatile tools to investigate basic biology and develop therapeutics. However, it remains a challenging task to evaluate their exact mechanisms of action. We identified two classes of inhibitors for the p97 ATPase: ATP competitive and allosteric. We showed that the allosteric p97 inhibitor, UPCDC-30245, does not affect two well-known cellular functions of p97, endoplasmic-reticulum-associated protein degradation and the unfolded p ...[more]