Factors That Affect the Rates of Adaptive and Nonadaptive Evolution at the Gene Level in Humans and Chimpanzees.

ABSTRACT: The rate of amino acid substitution has been shown to be correlated to a number of factors including the rate of recombination, the age of the gene, the length of the protein, mean expression level, and gene function. However, the extent to which these correlations are due to adaptive and nonadaptive evolution has not been studied in detail, at least not in hominids. We find that the rate of adaptive evolution is significantly positively correlated to the rate of recombination, protein length and gene expression level, and negatively correlated to gene age. These correlations remain significant when each factor is controlled for in turn, except when controlling for expression in an analysis of protein length; and they also generally remain significant when biased gene conversion is taken i

SUBMITTER: Soni V 

PROVIDER: S-EPMC8882387 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature