Combined Oxytocin and Cognitive Behavioral Social Skills Training for Social Function in People With Schizophrenia.

ABSTRACT:

Background

A significant proportion of people with schizophrenia are characterized by impaired ability to socially engage with others. The development of effective interventions for social functioning remains a central therapeutic challenge. Cognitive-behavioral social skills training (CBSST) has been found to improve social functioning in schizophrenia, but with only medium effect sizes. Intranasal oxytocin also has prosocial effects, but also only with modest effect sizes. This study assessed whether the addition of intranasal oxytocin to CBSST can strengthen their impact on social function.

Methods

Participants (N = 62) with schizophrenia or schizoaffective disorder entered a 24-week, double-blind, placebo-controlled, randomized clinical trial with a 3-month follow-up eva

SUBMITTER: Buchanan RW 

PROVIDER: S-EPMC8887701 | biostudies-literature | 2021 May-Jun 01

REPOSITORIES: biostudies-literature