Integrating Selection and Risk Assessment of Chemical Mixtures: A Novel Approach Applied to a Breast Milk Survey.

ABSTRACT:

Background

One of the main challenges of modern risk assessment is to account for combined exposure to the multitude of various substances present in food and the environment.

Objective

The present work proposes a methodological approach to perform chemical risk assessment of contaminant mixtures across regulatory silos regarding an extensive range of substances and to do so when comprehensive relevant data concerning the specific effects and modes of action of the mixture components are not available.

Methods

We developed a complete step-by-step approach using statistical methods to prioritize substances involved in combined exposure, and we used a component-based approach to cumulate the risk using dose additivity. The most relevant toxicological end point and the a

SUBMITTER: Crepet A 

PROVIDER: S-EPMC8893236 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature