Dataset Information

Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.

ABSTRACT:

Background

Coronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.

Methods

In this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital discharge. Medical history and laboratory examinations were performed while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD). Comparison with propensity score-matched cohort (control group) was performed at the acute (upon hospital admission) and follow-up (1 and 6 months) stages.

Results

Seventy-three patients diagnosed with COVID-19 (37% admitted in ICU) were recruited. FMD was significantly (p < 0.001) impaired in the COVID-19 group (1.65 ± 2.31%) compared to the control (6.51 ± 2.91%). ICU-treated subjects presented significantly impaired (p = 0.001) FMD (0.48 ± 1.01%) compared to those treated in the medical ward (2.33 ± 2.57%). During hospitalization, FMD was inversely associated with Interleukin-6 and Troponin I (p < 0.05 for all). Although, a significant improvement in FMD was noted during the follow-up (acute: 1.75 ± 2.19% vs. 1 month: 4.23 ± 2.02%, vs. 6 months: 5.24 ± 1.62%; p = 0.001), FMD remained impaired compared to control (6.48 ± 3.08%) at 1 month (p < 0.001) and 6 months (p = 0.01) post-hospital discharge.

Conclusion

COVID-19 patients develop a notable endothelial dysfunction, which is progressively improved over a 6-month follow-up but remains impaired compared to healthy controls subjects. Whether chronic dysregulation of endothelial function following COVID-19 could be accompanied by a residual risk for cardiovascular and thrombotic events merits further research.

SUBMITTER: Oikonomou E

PROVIDER: S-EPMC8893931 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.

Oikonomou Evangelos E Souvaliotis Nektarios N Lampsas Stamatios S Siasos Gerasimos G Poulakou Garyphallia G Theofilis Panagiotis P Papaioannou Theodore G TG Haidich Anna-Bettina AB Tsaousi Georgia G Ntousopoulos Vasileios V Sakka Vissaria V Charalambous Georgios G Rapti Vasiliki V Raftopoulou Sylvia S Syrigos Konstantinos K Tsioufis Costas C Tousoulis Dimitris D Vavuranakis Manolis M

Vascular pharmacology 20220303

<h4>Background</h4>Coronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.<h4>Methods</h4>In this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital ...[more]

PMID: 35248780

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Dataset Information

Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.

Background

Methods

Results

Conclusion

Publications

Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.

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