The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry.

ABSTRACT:

Background/objectives

The relationship between pre-existing diabetes mellitus (DM) and acute pancreatitis (AP) severity has not been established. We assessed the impact of pre-existing DM on AP severity in an international, prospectively ascertained registry.

Methods

APPRENTICE registry prospectively enrolled 1543 AP patients from 22 centers across 4 continents (8 US, 6 Europe, 5 Latin America, 3 India) between 2015 and 2018, and collected detailed clinical information. Pre-existing DM was defined a diagnosis of DM prior to AP admission. The primary outcome was AP severity defined by the Revised Atlanta Classification (RAC). Secondary outcomes were development of systemic inflammatory response syndrome (SIRS) or intensive care unit (ICU) admission.

Results

Pre-existin

SUBMITTER: Paragomi P 

PROVIDER: S-EPMC8894899 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature