Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin.

ABSTRACT:

Purpose

Gastric injury is a major issue for long-term administration of aspirin. In this work, we tried to explore the possibility of using BLG to alleviate aspirin-induced gastric injury, because of excellent abilities of BLG in loading drug molecules.

Methods

Various spectroscopic techniques and molecular docking methods were applied to investigate the interaction mechanism between BLG and aspirin. Animal experiments were performed to figure out the effects of taking aspirin-BLG on the stomach.

Results

Our results demonstrate that aspirin could bind with BLG to form stable aspirin-BLG complex (the binding constant K_b = 2.051 × 10³ M^-1). The formation process is endothermic (∆H>0) and the main acting force is hydrophobic force.

SUBMITTER: Chen J 

PROVIDER: S-EPMC8898184 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature