Associations between the Maternal Exposome and Metabolome during Pregnancy.

ABSTRACT:

Background

Maternal exposure to environmental chemicals during pregnancy can influence various maternal and offspring health parameters. Modification of maternal metabolism by environmental exposure may be an important pathway for these impacts. However, there is limited evidence regarding exposure to a wide array of chemicals and the metabolome during pregnancy.

Objectives

We investigated the relationship between the urinary exposome and metabolome during pregnancy.

Methods

Urine samples were collected in the first and third trimesters from 1,024 pregnant women recruited in prenatal clinics in Jiangsu Province, China. The exposome was analyzed using the first trimester sample with ultra-high performance liquid chromatography-high resolution accurate mass spectrometry

SUBMITTER: Chen M 

PROVIDER: S-EPMC8901044 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature