Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons.

ABSTRACT:

Background

Despite intense efforts to develop an objective diagnostic test for Parkinson's disease, there is still no consensus on biomarkers that can accurately diagnose the disease.

Objective

Identification of biomarkers for idiopathic Parkinson's disease (PD) may enable accurate diagnosis of the disease. We tried to find molecular and cellular differences in dopaminergic (DA) neurons derived from healthy subjects and idiopathic PD patients with or without rest tremor at onset.

Methods

We measured the expression of genes controlling dopamine synthesis, sequestration, and catabolism as well as the levels of corresponding metabolites and reactive oxygen species in midbrain DA neurons differentiated from induced pluripotent stem cells (iPSCs) of healthy subjects and PD

SUBMITTER: Ren Y 

PROVIDER: S-EPMC8901260 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature