Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports.

ABSTRACT:

Background

Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN.

Case presentation

Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects due to immunosuppressants. Both patients received intensive fresh FMT conducted through transendoscopic enteral tubing (TET) regularly for 6-7 months, and were followed up for a further 6 months. Partial clinical

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8901287 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature