Somatostatin Treatment for Ectopic ACTH Syndrome due to Pancreatic Neuroendocrine Tumors: Review of the Literature.

ABSTRACT:

Objectives

To analyze and summarize the effect of SSA treatment on EAS due to p-NETs (EAS-p-NETs).

Methods

Thirteen patients with EAS-p-NETs treated with SSAs at our center or described in the literature were included in this study. Clinical characteristics, laboratory data, imaging studies, histopathologic results, the effect of SSA treatment, and the prognosis of these EAS-p-NET patients were evaluated.

Results

Four males and 9 females with an average age of 42.9 years were included in the study. The mean duration of follow-up was 38.8 ± 28.2 months. As one of the combined treatment measures, SSAs controlled the levels of ACTH and cortisol in 9 of the 13 patients (69.2%). Partial response was observed in 3 patients (23.1%), stable disease in 2 patients (15.4%), and

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8901294 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature