Interactions of Age and Blood Immune Factors and Noninvasive Prediction of Glioma Survival.

ABSTRACT:

Background

Tumor-based classification of human glioma portends patient prognosis, but considerable unexplained survival variability remains. Host factors (eg, age) also strongly influence survival times, partly reflecting a compromised immune system. How blood epigenetic measures of immune characteristics and age augment molecular classifications in glioma survival has not been investigated. We assess the prognostic impact of immune cell fractions and epigenetic age in archived blood across glioma molecular subtypes for the first time.

Methods

We evaluated immune cell fractions and epigenetic age in archived blood from the University of California San Francisco Adult Glioma Study, which included a training set of 197 patients with IDH-wild type, 1p19q intact, TERT wild type

SUBMITTER: Molinaro AM 

PROVIDER: S-EPMC8902347 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature