Quantitative proteomic analysis of serum-purified exosomes identifies putative pre-eclampsia-associated biomarkers.

ABSTRACT:

Background

The high incidence of pre-eclampsia, which affects 2-7% of all pregnancies, remains a major health concern. Detection of pre-eclampsia before the appearance of clinical symptoms is essential to allow early intervention, and would benefit from identification of plasma/serum biomarkers to help guide diagnosis and treatment. Liquid biopsy has emerged as a promising source of protein biomarkers that circumvents some of the inherent challenges of proteome-wide analysis of plasma/serum. In this respect, purified exosomes have the added benefit of being carriers of intercellular communication both in physiological and pathological conditions.

Methods

We compared the protein complement of purified exosomes from three different collections of control and pre-eclamptic seru

SUBMITTER: Navajas R 

PROVIDER: S-EPMC8903615 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature