Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics.

ABSTRACT:

Background

Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in cancer. Quantitative proteomic profiling of circulating microvesicles and exosomes can be a high-throughput platform for discovery of novel molecular insights and putative markers. Hence, this study aimed to investigate proteome dynamics of plasma-derived microvesicles and exosomes in newly diagnosed SCLC patients to improve early detection.

Methods

Plasma-derived microvesicles and exosomes from 24 healthy controls and 24 SCLC patients were isolated from plasma by either high-speed- or ultracentrifugation. Proteins derived from these extracellular vesicles we

SUBMITTER: Pedersen S 

PROVIDER: S-EPMC8903681 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature