Genistein protects against ultraviolet B-induced wrinkling and photoinflammation in in vitro and in vivo models.

ABSTRACT:

Background

Chronic exposure to ultraviolet (UV) rays causes severe skin damage by inducing oxidative stress and inflammation. Identifying a safe and natural substance for skin protection is a crucial research goal.

Objective

The aim of this study was to clarify the effects of genistein on skin inflammation and photoaging by using 3 models (humans: skin parameters; animals: wrinkle formation; and cells: anti-inflammatory effects).

Methods

Food frequency questionnaire data and serum and skin parameter data from 120 volunteers (a group with a genistein-rich diet [RG group] and a control group). Human keratinocytes were pretreated with genistein before ultraviolet B (UVB) irradiation. Genistein was topically applied to the dorsal skin of rats.

Results

The blood sam

SUBMITTER: Tang SC 

PROVIDER: S-EPMC8903702 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature