Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity.

ABSTRACT:

Background

Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with α-Synucleinopathy (α-Syn, i.e., Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy), a consistent pattern of dysfunction remains unclear. We aim to investigate network dysfunction in patients with α-Syn through a meta-analysis.

Methods

Whole-brain seed-based resting-state functional connectivity studies (published before September 1st, 2020 in English) comparing α-Syn patients with healthy controls (HC) were retrieved from electronic databases (PubMed, Web of Science, and EMBASE). Seeds from each study were categorized into networks by their location within a priori functional networks. Seed-based effect size mapping with Permutation of Sub

SUBMITTER: Tang S 

PROVIDER: S-EPMC8904227 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature