⁹⁹Tc-Methylene Diphosphonate Treatment is Safe and Efficacious for Osteoporosis in Postmenopausal Differentiated Thyroid Cancer Patients Undergoing TSH Suppression: A Three-Center Non-Randomized Clinical Study.

ABSTRACT:

Objective

To investigate the effects of ⁹⁹Tc-methylene diphosphonate (⁹⁹Tc-MDP) on osteoporosis (OS) in postmenopausal patients with differentiated thyroid cancer (DTC) under thyroid stimulating hormone (TSH) suppression.

Patients and methods

Patients (n = 142) were divided into two groups: (1) ⁹⁹Tc-MDP (n = 70) and (2) alendronate (n = 72) treatments (NCT02304757). Bone mineral density (BMD) in the lumbar spine and hip was evaluated by DXA, along with bone turnover markers, safety, and quality of life (QOL) using SF-36 at three time points: before treatment and at 6 and/or 12 months after treatment.

Results

The percentage change of BMD in total lumbar spine or hip showed no significant difference throughout the study (P > 0.025).

SUBMITTER: Xie J 

PROVIDER: S-EPMC8906701 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature