Evaluation of acute and sub-acute toxicity profile of 5-methylcoumarin-4β-glucoside in mice.

ABSTRACT: Vernonia glaberrima leaves are traditionally used to alleviate bodily pain, skin cancer, and other skin-related disorders. The purpose of the study was to investigate the acute and sub-acute toxicity of 5-methylcoumarin-4β-glucoside, a promising chemotherapeutic agent against colon cancer isolated from the leaves of Vernonia glaberrima. 5-methylcoumarin-4β-glucoside was isolated from the methanol leaf extract of Vernonia glaberrima following a previously described method. The acute toxicity study involved a two-phase 24 h observation for signs of mortality and toxicity following single oral dose administration of the isolated compound. For the sub-acute study, four groups of mice, averagely aged eight weeks, were administered graded doses of the compound (250, 500 and

SUBMITTER: Abubakar B 

PROVIDER: S-EPMC8914464 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature