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Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-γ-glutamate and calcium cations.

ABSTRACT: We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer. γ-PGA with ALN (γ-PGA-ALN) forms the hydrogel in the aqueous solution containing CaCl₂. The hydrogel shows 2000% of stretchability and reversible stretching without failure at a strain of 250%. The fracture strain and stress are tunable by varying the concentration of either γ-PGA-ALN or CaCl₂, indicating the importance of fine-tuning of the density of the cross-linkage to control the mechanical properties of the hydrogel. We believe the biodegradable polymer based highly stretchable hydrogel has potential for use in various fields such as tissue engineering.

SUBMITTER: Nakamoto M

PROVIDER: S-EPMC8914556 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-γ-glutamate and calcium cations.

Nakamoto Masahiko M Noguchi Moe M Nishiguchi Akihiro A Mano João F JF Matsusaki Michiya M Akashi Mitsuru M

Materials today. Bio 20220301

We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer. γ-PGA with ALN (γ-PGA-ALN) forms the hydrogel in the aqueous solution containing CaCl<sub>2</sub>. The hydrogel shows 2000% of stretchability and reversible stretching without failure at a strain of 250%. The fracture strain and stress are tunable by varying the concentration of either γ-PGA-ALN or Ca ...[more]

PMID: 35280331

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