Different FreeSurfer versions might generate different statistical outcomes in case-control comparison studies.

ABSTRACT:

Purpose

Neuroimaging pipelines have long been known to generate mildly differing results depending on various factors, including software version. While considered generally acceptable and within the margin of reasonable error, little is known about their effect in common research scenarios such as inter-group comparisons between healthy controls and various pathological conditions. The aim of the presented study was to explore the differences in the inferences and statistical significances in a model situation comparing volumetric parameters between healthy controls and type 1 diabetes patients using various FreeSurfer versions.

Methods

T1- and T2-weighted structural scans of healthy controls and type 1 diabetes patients were processed with FreeSurfer 5.3, FreeSurfer 5.3 HC

SUBMITTER: Filip P 

PROVIDER: S-EPMC8916973 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature