Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence.

ABSTRACT:

Background

Although prenatal chemical exposures influence neurobehavior, joint exposures are not well explored as risk factors for internalizing disorders through adolescence.

Objective

To evaluate associations of prenatal organochlorine and metal exposures, considered individually and as a mixture, with mid-childhood and adolescent internalizing symptoms.

Methods

Participants were 468 children from a prospective cohort recruited at birth (1993-1998) in New Bedford, Massachusetts. Organochlorines (hexachlorobenzene, p,p'-dichlorodiphenyl dichloroethylene, polychlorinated biphenyls) and metals (lead, manganese) were analyzed in cord blood. Internalizing symptoms (anxiety, depressive, somatic) were assessed via multiple informants on the Conners' Rating Scale (CRS) at 8

SUBMITTER: Rokoff LB 

PROVIDER: S-EPMC8917058 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature