Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial.

ABSTRACT:

Background

Treatment with erythropoietin is well established for anemia in chronic kidney disease patients but not well studied in acute kidney injury.

Methods

This is a multicenter, randomized, pragmatic controlled clinical trial. It included 134 hospitalized patients with anemia defined as hemoglobin < 11 g/dL and acute kidney injury defined as an increase of serum creatinine of ≥ 0.3 mg/dL within 48 h or 1.5 times baseline. One arm received recombinant human erythropoietin 4000 UI subcutaneously every other day (intervention; n = 67) and the second received standard of care (control; n = 67) during the hospitalization until discharge or death. The primary outcome was the need for transfusion; secondary outcomes were death, renal recovery, need for dialysis.

Results

SUBMITTER: Aoun M 

PROVIDER: S-EPMC8917943 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature