Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients.

ABSTRACT:

Objective

SARS-CoV-2 vaccinations have demonstrated vaccine-immunogenicity in healthy volunteers, however, efficacy in immunosuppressed patients is less well characterised. There is an urgent need to address the impact of immunosuppression on vaccine immunogenicity.

Methods

Serological, T-cell ELISpot, cytokines and immunophenotyping were used to assess vaccine responses (either BNT162b2 mRNA or ChAdOx1 nCoV-19) in double-vaccinated patients receiving immunosuppression for renal transplants or haematological malignancies (n = 13). Immunological responses in immunosuppressed patients (VACC-IS) were compared to immunocompetent vaccinated (VACC-IC, n = 12), unvaccinated (UNVACC, n = 11) and infection-naïve unvaccinated (HC, n = 3) cohorts.

Results

No significant differen

SUBMITTER: Mohanraj D 

PROVIDER: S-EPMC8920407 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature