Managing of Dyslipidaemia Characterized by Accumulation of Triglyceride-Rich Lipoproteins.

ABSTRACT:

Purpose of review

The accumulation of triglyceride-rich lipoproteins (TRLs) in plasma in patients with familial chylomicronaemia syndrome (FCS) or severe hypertriglyceridemia is associated with an increased risk of potentially life-threatening pancreatitis. Elevated TRL levels have also been suggested to contribute to atherosclerotic cardiovascular disease (ASCVD). This review provides the latest progress that has been made in this field of research.

Recent findings

Apolipoprotein C-III and angiopoietin-like protein 3 play key roles in the metabolism of TRLs. Targeting their production in the liver or their presence in the circulation effectively reduces triglycerides in patients with FCS or severe hypertriglyceridemia. Attempts to reduce triglyceride synthesis in the small

SUBMITTER: Visser J 

PROVIDER: S-EPMC8924084 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature