Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.

ABSTRACT:

Objectives

To examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSD_REX) symptoms and the severity of and positive screen for traumatic loss-related PTSD.

Methods

Data were analysed from 631 US veterans who endorsed 'unexpected death of a loved one' as their 'worst' traumatic event. Multivariable models evaluated the association between PRS for PTSD_REX, attachment style, and their interaction in predicting severity and positive screen for PTSD. A gene enrichment analysis was conducted to identify possible molecular mechanisms underlying the association between PTSD_REX PRS and PTSD.

Results

PTSD_REX PRS (β = 0.17; odd

SUBMITTER: Asch RH 

PROVIDER: S-EPMC8925016 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature