Correlation and prognostic implications of intratumor and tumor draining lymph node Foxp3⁺ T regulatory cells in colorectal cancer.

ABSTRACT:

Background

The prognostic value of intratumor T regulatory cells (Tregs) in colorectal cancer (CRC) was previously reported, but the role of these cells in tumor draining lymph nodes (TDLNs) was less addressed.

Methods

A total of 150 CRC stages I-IV were retrospectively enrolled. Intratumor and TDLN Tregs were examined by immunohistochemical assay. The association of these cells was estimated by Pearson correlation. Survival analyses of subgroups were conducted by Kaplan-Meier curves, and the log-rank test and risk factors for survival were tested by the Cox proportional hazard model.

Results

High accumulation of Tregs in tumors was significant in patients with younger age and good histological grade, where enrichment of these cells in TDLNs was more apparent in those

SUBMITTER: Yan B 

PROVIDER: S-EPMC8925044 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature