Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

ABSTRACT:

Rationale & objective

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD.

Study design

Neuroimaging substudy of a randomized trial.

Setting & participants

A subset of participants in the Systolic Blood Pressure Intervention Trial (SPRINT) who underwent brain magnetic resonance imaging studies. Presence of baseline CKD was assessed by estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR).

Intervention

Participants were randomly assigned to intensive (systolic BP <120 mm Hg) versus standard (systolic BP <140 mm Hg) BP lowering.

Outcomes

The

SUBMITTER: Kurella Tamura M 

PROVIDER: S-EPMC8926938 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature