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In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric Cu^II Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.

ABSTRACT: Formation of nitro radical anion (-NO₂ ^•-) and other reduction products of 5-nitroimidazoles, although important for antimicrobial activity, makes the drugs neurotoxic. Hence, an appropriate generation and their role in the free radical pathway needs proper realization. This was attempted by studying the action of tinidazole and its Cu^II complexes on model targets (nucleic acid bases and calf thymus DNA). Results obtained were correlated with studies on biological species where prevention of biofilm formation on Staphylococcus aureus and Pseudomonas aeruginosa was followed. Tinidazole and its Cu^II complexes subjected to electrochemical reduction in aqueous solution, under de-aerated conditions, interact with model nucleic acid bases

SUBMITTER: Nandy P

PROVIDER: S-EPMC8928527 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric Cu^II Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric CuII Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric Cu^II Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.