Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.

ABSTRACT:

Context

Obstructive sleep apnoea (OSA) causes chronic intermittent hypoxia (CIH), which results in mitochondrial dysfunction and generates reactive oxygen species (ROS) in the heart. Excessive free iron could accelerate oxidative damage, which may be involved in this process. Banxia-Houpu decoction (BHD) was reported to improve the apnoea hypopnoea index in OSA patients, but the specific mechanism was still unclear.

Objective

To investigate whether BHD could reduce CIH-induced heart damage by regulating iron metabolism and mitochondrial function.

Materials and methods

C57BL/6N mice were randomly divided into control, CIH and BHD groups. Mice were exposed to CIH (21 - 5% O₂, 20 times/h, 8 h/d) and administered BHD (3.51, 7.01 and 14.02 g/kg, intragastrically

SUBMITTER: Song JX 

PROVIDER: S-EPMC8928803 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature