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A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.

ABSTRACT: SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC8931246 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.

Zhang Yunjia Y Li Boxun B Cananzi Sergio S Han Chuanhui C Wang Lei-Lei LL Zou Yuhua Y Fu Yang-Xin YX Hon Gary C GC Zhang Chun-Li CL

Proceedings of the National Academy of Sciences of the United States of America 20220307 11

SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerat ...[more]

PMID: 35254903

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A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

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