Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.

ABSTRACT:

Purpose

Cardiovascular disease (CVD) is the leading cause of death in adults in the United States, yet the benefits of genetic testing are not universally accepted.

Methods

We developed the "HeartCare" panel of genes associated with CVD, evaluating high-penetrance Mendelian conditions, coronary artery disease (CAD) polygenic risk, LPA gene polymorphisms, and specific pharmacogenetic (PGx) variants. We enrolled 709 individuals from cardiology clinics at Baylor College of Medicine, and samples were analyzed in a CAP/CLIA-certified laboratory. Results were returned to the ordering physician and uploaded to the electronic medical record.

Results

Notably, 32% of patients had a genetic finding with clinical management implications, even after excluding PGx results, includin

SUBMITTER: Murdock DR 

PROVIDER: S-EPMC8931845 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature