Intracellular metabolic adaptation of intraepithelial CD4⁺CD8αα⁺ T lymphocytes.

ABSTRACT: Intestinal intraepithelial lymphocytes (IELs), the first line of defense against microbial and dietary antigens, are classified as natural or induced based on their origin and receptor expression. Induced CD4⁺CD8αα⁺TCRβ⁺ T cells (double positive, DP_IELs) originated from CD4⁺CD8α^-TCRβ⁺ T cells (single positive, SP_IELs) increase with aging. However, the metabolic requirements and the metabolic-related genes in IEL development remain unclear. We determined that the intraepithelial compartment is hypoxic in the presence of microbes and DP_IELs increased more than natural IELs in this location. Moreover, DP_IELs consumed less oxygen and glucose and exhibited unique alterations in mitochon

SUBMITTER: Harada Y 

PROVIDER: S-EPMC8933710 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature