Near-roadway air pollution, immune cells and adipokines among obese young adults.

ABSTRACT:

Background

Air pollution has been associated with metabolic disease and obesity. Adipokines are potential mediators of these effects, but studies of air pollution-adipokine relationships are inconclusive. Macrophage and T cells in adipose tissue (AT) and blood modulate inflammation; however, the role of immune cells in air pollution-induced dysregulation of adipokines has not been studied. We examined the association between air pollution exposure and circulating and AT adipokine concentrations, and whether these relationships were modified by macrophage and T cell numbers in the blood and AT.

Methods

Fasting blood and abdominal subcutaneous AT biopsies were collected from 30 overweight/obese 18-26 year-old volunteers. Flow cytometry was used to quantify T effector (Teff, in

SUBMITTER: Rahman MM 

PROVIDER: S-EPMC8933931 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature