DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.

ABSTRACT:

Background

Environmental exposures in utero which modify DNA methylation may have a long-lasting impact on health and disease in offspring. We aimed to identify and replicate previously published genomic loci where DNA methylation changes are attributable to in utero exposures in the NutriGen birth cohort studies Alliance.

Methods

We reviewed the literature to identify differentially methylated sites of newborn DNA which are associated with the following five traits of interest maternal diabetes, pre-pregnancy body mass index (BMI), diet during pregnancy, smoking, and gestational age. We then attempted to replicate these published associations in the Canadian Healthy Infant Longitudinal Development (CHILD) and the South Asian birth cohort (START) cord blood epigenome-wide da

SUBMITTER: Akhabir L 

PROVIDER: S-EPMC8933946 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature