Dataset Information

The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

In this study, we performed a bidirectional mendelian randomization analysis on circulating cytokines and critically ill COVID-19.

Methods

Both the exposure and outcome data were obtained from public genome wide association study (GWAS) database. We extracted independent instrumental variables from exposure at genome level significance (P < 5 × 10^-8). Wald ratio or inverse variance weighted (IVW) method were used for estimating the causal relationships between circulating cytokines and critically ill COVID-19.

Results

Only IL5 (cytokines to critically ill COVID-19 direction) and bNGF, IL8 (critically ill COVID-19 to cytokines direction) showed suggestive causal relations. However, these associations lost significance after FDR correction. Another validation data set of critically ill COVID-19 did not confirm these associations, either.

Conclusions

Our Mendelian randomization did not find causal relationships between analyzable circulating cytokines and critically ill COVID-19.

SUBMITTER: Yang Y

PROVIDER: S-EPMC8934535 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.

Yang Yu Y Xiaohui Yang Y Miao Sui S Yingshuo Zhong Z

Journal of global health 20220219

<h4>Background</h4>In this study, we performed a bidirectional mendelian randomization analysis on circulating cytokines and critically ill COVID-19.<h4>Methods</h4>Both the exposure and outcome data were obtained from public genome wide association study (GWAS) database. We extracted independent instrumental variables from exposure at genome level significance (<i>P</i> < 5 × 10<sup>-8</sup>). Wald ratio or inverse variance weighted (IVW) method were used for estimating the causal relationships ...[more]

PMID: 35356648

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Dataset Information

The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.

Background

Methods

Results

Conclusions

Publications

The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.

Similar Datasets

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