Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.

ABSTRACT:

Background

Emerging data from longitudinal studies suggest that preserved ratio impaired spirometry (PRISm), defined by proportionate reductions in FEV₁ and FVC, is a heterogeneous population with frequent transitions to other lung function categories relative to individuals with normal and obstructive spirometry. Controversy regarding the clinical significance of these transitions exists (eg, whether transitions merely reflect measurement variability or noise).

Research question

Are individuals with PRISm enriched for transitions associated with substantial changes in lung function?

Study design and methods

Current and former smokers enrolled in the Genetic Epidemiology of COPD (COPDGene) study with spirometry available in phases 1 through 3 (enrollment, 5

SUBMITTER: Wan ES 

PROVIDER: S-EPMC8941606 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature