Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults.

ABSTRACT:

Objective

Despite the known benefit of vitamin D in reducing sarcopenia risk in older adults, its effect against muscle loss in the young population is unknown. We aimed to examine the association of serum 25-hydroxy vitamin D [25(OH)D] level and its changes over time with the risk of incident low muscle mass (LMM) in young and middle-aged adults.

Design

This study is a cohort study.

Methods

The study included Korean adults (median age: 36.9 years) without LMM at baseline followed up for a median of 3.9 years (maximum: 7.3 years). LMM was defined as the appendicular skeletal muscle (ASM) mass by body weight (ASM/weight) of 1 s.d. below the sex-specific mean for the young reference group. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95%

SUBMITTER: Kim Y 

PROVIDER: S-EPMC8942330 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature