Ontogeny of circulating lipid metabolism in pregnancy and early childhood - a longitudinal population study.

ABSTRACT:

Background

There is mounting evidence that in utero and early life exposures may predispose an individual to metabolic disorders in later life; and dysregulation of lipid metabolism is critical in such outcomes. However, there is limited knowledge about lipid metabolism and factors causing lipid dysregulation in early life that could result in adverse health outcomes in later life. We studied the effect of antenatal factors such as gestational age, birth weight, and mode of birth on lipid metabolism at birth; changes in the circulating lipidome in the first 4 years of life and the effect of breastfeeding in the first year of life. From this study, we aim to generate a framework for deeper understanding into factors effecting lipid metabolism in early life, to provide early interven

SUBMITTER: Burugupalli S 

PROVIDER: S-EPMC8942471 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature