Dysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment.

ABSTRACT:

Background

Microbes have been shown to contribute to gastric cancer (GC), gastric bacteria and viruses are associated with gastric carcinogenesis. However, the relationship between gastric fungi and GC is still unclear. Our aim was to evaluate the gastric fungal microbiota in the GC microenvironment.

Methods

Gastric fungal microbiome profiling was performed with internal transcribed spacer (ITS) rDNA sequencing in primary tumor and corresponding paired normal mucosal tissues from 61 GC patients. Differences in microbial composition, taxa diversity, and predicted function were further analyzed.

Results

Dysbiosis of gastric mucosal fungal microbiome was observed between the tumor and normal groups in GC. The tumor group had a higher abundance of certain taxa than the no

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8942701 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature