Effect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes.

ABSTRACT:

Introduction

Impaired awareness of hypoglycemia, clinically reflected by the inability to timely detect hypoglycemia, affects approximately 25% of the people with type 1 diabetes. Both altered brain lactate handling and increased cerebral blood flow (CBF) during hypoglycemia appear to be involved in the pathogenesis of impaired awareness of hypoglycemia. Here we examine the effect of lactate on CBF during hypoglycemia.

Research design and methods

Nine people with type 1 diabetes and normal awareness of hypoglycemia underwent two hyperinsulinemic euglycemic-hypoglycemic (3.0 mmol/L) glucose clamps in a 3T MR system, once with sodium lactate infusion and once with sodium chloride infusion. Global and regional changes in CBF were determined using pseudocontinuous arterial spin

SUBMITTER: van Meijel LA 

PROVIDER: S-EPMC8943734 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature